Mycobacterium avium subspecies paratuberculosis (MAP) is the organism responsible for a chronic, intestinal inflammatory disease found in domestic livestock, including cattle, deer, sheep and goats. Infection generally occurs early in life, and many infected animals become chronic carriers. Unless testing is done, paratuberculosis or Johne’s disease can exist undetected in a herd for years. Furthermore, MAP has also been implicated as a possible cause of Crohn’s disease in humans. Scientists at the University of Göttingen developed an improved PCR diagnostic test for fast and early detection of Paratuberculosis.
Unless measures are taken to control or eradicate the organism, the prevalence of infection gradually increases in the herd and greater numbers of animals become clinically ill. Economic impact of Johne’s disease in livestock may include premature culling, decreased milk production, possible breeding problems and loss of valuable animals and genetic potential.
Scientists at the University of Göttingen developed an improved PCR diagnostic test for fast and early detection of Paratuberculosis. This test has great sensitivity, whereby maintaining robustness and is extremely specific for MAP. Proof of concept has been achieved in various samples, including feces, blood, milk, sperm and tissue samples.
In vivo PoC on domestic livestock.
The international patent application has been nationalized in Europe, USA, Canada and China (Applicant: Georg-August-Universität Göttingen, public law foundation).
WO2013160434, PhD thesis Pia Münster, University of Göttingen, 2012
Dr. Stefan Uhle
Patent Manager Life Science
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