Tissue engineering has advanced over the last two decades and has the potential to replace traditional cell-based assays. Today, preclinical drug or toxin screening still relies on cell culture with poor predictive power. Scientists at the University of Göttingen have developed a new device for automated and reliable tissue engineering and drug testing.
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The COVID-19 pandemic has emerged as the most serious health crisis in modern times. To combat RNA viral infections like SARS, Influenza, Hepatitis C, HIV or even Ebola a new combination therapeutic approach of pyrimidine analogues and pyrimidine biosynthesis inhibitors has been discovered.
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A combination of sample Epxansion and a well suited Nanoscopy method allows to take images that can visualize the shape of protein clusters and even can define positions of single amino acids inside proteins. The method has great potential to be used for 3D structure determination, drug design or diagnostic approaches.
By structure guided rational mutagenesis a superior Channelrhodopsin variant (ChReef) was developed from the Protein ChRmine. A desensitization effect could be reduced by a factor of three and at the same time the light induced photo-current of these variants is five times higher. This allows for an activation of neurons with lower light doses and/or a reduced expression level, which will reduce side effects.
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Newly developed drugs stabilize the Ca2+ level in heart muscle cells and can prevent heart failure. These novel drug-candidates allow a simultaneous modulation of the function of the two transporters RyR2 and SERCA, which have key roles in the Ca2+ housekeeping and signaling pathway.
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Vertical Algebraic LIght sheet Deconvolution (VALID) combines theoretical considerations and the usage of empiric image data for deconvolving 3D image stacks. By using an iterative approach, VALID is able calculate the true dimensions of a light sheet, which allows to precisely subtract bleed-through signal between the single slices - at each position of the light sheet in 3D.
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Pan-Coronavirus Therapy using a Cas13-guideRNA system. The antiviral effect is based on an Cas13-guideRNA-AAV vector with up to five guideRNAs, which target and disrupt the genome of the Coronavirus - blocking viral replication. A therapeutic effect was proven in vivo in the SARS-CoV2 Hamster Model.
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The present invention relates to a method for producing dry pet food articles from puffed corn in all kinds of shapes and forms with good taste and low caloric value.
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A simple metric, based on local changes in the fluorescence lifetime was found to reflect the quality of the STED focus. This metric can be used to correct abberations fast, on-line and continuously over the whole image, using a simple deformable mirror and an elaborated algorythm.
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FLIX-NANOPORE has been developed to provide the first rapid and genome-wide determination of transcription factor binding sites and transcription factor binding sequences. Transcription factors are cross-linked to DNA at the DNA binding sequence using a femtosecond laser. This is followed by proteolysis, which leaves only individual amino acids covalently bound to their DNA-binding sequence. In the nanopore, the complexes of covalently bound amino acids and nucleobases are sequenced simultaneously, allowing us to identify the transcription factor binding sites and the corresponding sequence.
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Our cutting-edge technology revolutionizes gene regulation by precisely controlling the translation of specific target genes. By modulating the nuclear export of corresponding mRNA, we can either enhance or inhibit gene expression with remarkable specificity. This innovation stems from breakthrough research revealing how defined anti-sense RNAs bind to cognate mRNA in a sequence-specific manner, facilitating its export from the nucleus and driving efficient translation in the cytoplasm. Empower your research with this advanced solution, designed to unlock new possibilities in therapeutic gene therapies.
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Heart tissue engineering using stem cells is a recently developed technique to construct a three dimensional cell structure from cardiomyocytes or directly from progenitor cells. Scientists at the University of Göttingen developed two new and fully defined methods for serum-free production of engineered human heart muscles.
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Cardiovascular disease is the number one cause of death worldwide. Scientists at the University Medical Center Göttingen developed a gene therapy (TBX5 re-expression) for use in the prevention and acute treatment of a heart disease and associated complications (e.g. cardiac arrhythmia and sudden cardiac death).
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Gene therapies are irreversible and not controlable in case of side effects. We offer a pharmacologically controlled one-vector expression system of a therapeutic factor (i.e. GDNF) with zero background expression, based on mifepristone (Mfp)-Gene Switch system, for the therapy of neurological diseases.
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Scientists at the University Medical Center Göttingen, Germany developed a reproducible, robust and fully defined method for serum-free production of human bio-engineered neuronal organoids (BENOs) from stem cells. This new method will allow for reproducible production of oganoids with fully functional neuronal network activity.
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Paratuberculosis or Johne's disease is a contagious, chronic and also fatal bacterial infection, which generally occurs early in life. The disease can exist undetected in a herd for many years. Scientists at the University of Göttingen developed an improved PCR diagnostic test for fast and early detection of Paratuberculosis.
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Scientists at the University of Veterinary Medicine Hanover developed a new marker vaccine for classical swine fever based on chimeric pestiviruses with improved DIVA (Differentiating Infected from Vaccinated Animals) properties. The used marker Erns is a chimeric sequence of two different and remotely related pestiviruses.
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Due to the large OTOF size a one-vector delivery has remained challenging.Our technology: Gene-therapy of the otoferlin gene (OTOF) with overloaded AAV virus mediated delivery into the cochlea. In vivo proof-of-concept successfully achieved.
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All-in-one construct dCas9-TET3CD-(target gene)-sgRNA for targeted fibrosis therapy through demethylation of the genes RASAL1, LRFN2, KLOTHO (i.e. in heart, kidney, liver, lung, cancer). Normal re-expression of these genes has been achieved successfully in vitro and in vivo as well as a reduction of fibrosis.
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Scientists at the University of Veterinary Medicine Hanover, Germany developed a new test for a genetic defect causing bleeding disorders in dogs. It allows breeders to improve targeted mating by omitting genetic carriers to avoid genetic diseases in offsprings. This is especially important for autosomal recessive mutations.
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Scientists at the University of Göttingen developed a novel, proprietary antibody for the therapy and/or diagnosis of Alzheimer's Disease (AD) through the targeting of specifically pyro-Glu-Amyloid beta peptides.
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Scientists at the University of Göttingen have developed a variety of monoclonal antibodies, which are used for research purposes, but also find applications in the development of diagnostic tests and therapeutic solutions. Here you will find a list of all antibodies that currently are available for licensing. Details
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The Culture Collection of Algae at the Georg August University Göttingen is one of the five largest collections of living microscopic algae. Founded in 1954, the SAG collection today holds around 2.250 strains from almost all evolutionary lineages of algae and cyanobacteria (1202 named species from 521 genera), mostly isolated from freshwater or terrestrial habitats.
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Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract. GISTs occur in 10-20 per one million people. Thus, GIST has been named as an orphan drug disease. Scientists at the University of Göttingen developed a new animal drug screening model for GIST.
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Shar-Pei Autoinflammatory Disease (SPAID) is a complex inflammatory disease. Typical signs are recurrent bouts of fever, inflammations of the ear, arthritis and a reddened skin. The dogs can also develop amyloidosis. Scientists at the University of Veterinary Medicine Hannover developed a genetic test for SPAID predisposition.
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New transgenic mouse model for sporadic Alzheimer's Disease. It does not have any mutation and it shows neurological deficits by transgenic over-expressing a major form of amyloid beta peptides (N-truncated Abeta 4-42) found in the brain of AD patients.
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Arthritic diseases are conditions involving damages to the joints and/or cartilage. A primary form of arthritis is for example rheumatoid arthritis, which affects over 21 million people worldwide. Scientists at the University of Göttingen have developed a new animal drug screening model for arthritic diseases.
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Scientists at the University Göttingen developed a monoclonal antibody against a biotinylable peptid (Epitope-Tag) called AP-tag or Avi Tag. This small peptide served as a substrate mimic for biotin ligase (BirA). Anti-AP antibodies are useful tools in the analysis of AP-tag fusion proteins.
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